• br Conclusions br Acknowledgements This work

  2019-05-23

  

  Conclusions Acknowledgements This work was supported by Bloodwise, the International Myeloma Foundation and a Marie Curie Career Integration Grant from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° [294160]. The osteoblast in normal bone physiology

• Splicing machinery dysfunctions have been associated

  2019-05-23

  

  Splicing machinery dysfunctions have been associated to CLL, in particular gene mutations (splicing factor 3B subunit 1) which are present in about 15% of patients . To our knowledge, no gene mutation has ever been detected in CLL. In order to broaden our knowledge on the frequency of splicing mu

• Studies using fixed site monitoring data rather than persona

  2019-05-23

  

  Studies using fixed-site monitoring data rather than personal monitoring data are subject to misclassification of the exposure because fixed site monitors do not account for individual mobility that affect exposure. Although, this typically results in non-differential exposure misclassification that

• br Unacceptably high rates of

  2019-05-23

  

  Unacceptably high rates of adverse outcomes persist for childbearing women and infants, including maternal and newborn mortality, stillbirth, and short-term and long-term morbidity. In light of the challenges to achieve the UN Sustainable Development Goals, it is timely to reconsider priorities fo

• br Stephanie Topp points to

  2019-05-23

  

  Stephanie Topp points to the limitations of quality measurement in Commission on High Quality Health Systems (HQSS Commission; May, 2017) that might not fit the real-world contexts of low-income and middle-income countries (LMICs). She also takes issue with a narrow set of generic indicators and

• As Canadians queue to vote in the federal election

  2019-05-22

  

  As Canadians queue to vote in the federal election next week, some will be uncomfortable knowing that the new Fair Elections Act that requires an official photo identification will overwhelmingly discriminate against those who are least likely to produce it—the very groups cited by UNCOHR. Many Cana

• Diversos trabajos coinciden en mencionar el impacto positivo

  2019-05-22

  

  Diversos trabajos coinciden en mencionar el impacto positivo que la auh ha tenido en términos de inclusión y justicia social frente Phos-tag Biotin BTL-104 la situación donde sólo había asignación familiar contributiva, a partir de variables macroeconómicas como la modificación de tasas de pobreza

• Concurrent with the clinical evaluation

  2019-05-22

  

  Concurrent with the clinical evaluation of the family, the genetic findings from a molecular autopsy may help to elucidate the cause of death in the decedent, as well as provide a basis for cascade genetic testing of at-risk family members. Offering cascade genetic testing to asymptomatic relatives

• This Ca overload activates the

  2019-05-22

  

  This Ca2+ overload activates the forward mode of the Na+/Ca+ exchanger (NCX), increases the transient inward current (Iti), and induces ventricular arrhythmias due to delayed after depolarizations (DADs). Subtypes of CPVT Several subtypes of CPVT have been reported (Table 1). The most common typ

• La Historia natural o moral de las

  2019-05-22

  

  5. La Historia natural o moral de las Indias de Joseph de Acosta (1540-1600), impresa en 1592, recoge con gran concisión y puntualidad hechos históricos al tiempo que explica los aspectos de la naturaleza que, desde su perspectiva, no han sido tratados en forma adecuada por las fuentes anteriores. E

• Recordemos que en diciembre de se celebr en

  2019-05-22

  

  Recordemos que en diciembre de 1938 se celebró en Lima la Octava Conferencia Internacional de los Estados Americanos, donde se analizó la Segunda Guerra Mundial y las posibles consecuencias para América, así como el rol de Estados Unidos, aunque no se aprobó ninguna acción colectiva. La Declaración

• Cuando se hable del testimonio como

  2019-05-22

  

  Cuando se hable del testimonio como género literario, así como de la miríada de genealogías que lo describen como la última expresión de un movimiento que ya había caracterizado aconitine la historia literaria de Latinoamérica, donde el cruce entre la política y la estética es una constante desde la

• br Materials and methods br Results br

  2019-05-22

  

  Materials and methods Results Discussion The treatment regimen used in this study is generally safe and well tolerated. The process of generating therapeutic numbers of CART-138 Bindarit by limiting their dilutions proved to be quite difficult; however, the target cell dose was reached with

• In addition to inducing IKs dysfunction through

  2019-05-22

  

  In addition to inducing IKs dysfunction through dominant-negative loss-of-function effects and defective channel trafficking, mutations in KCNQ1 suppress IKs channel function by reducing the channel affinity of interacting proteins [68,69]. Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor

• br Conclusion br Financial support This research was support

  2019-05-22

  

  Conclusion Financial support This research was supported by a grant from the ׳Gerencia de Salud, Consejería de Sanidad, Junta de Castilla y Leon׳ [GRS 308/A/08] and ‘Caja Burgos Foundation’ [Convocatoria 2007].The funding organization had no involvement in the study. Clinical trial registra

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