• br STAR Methods br Introduction Secretase is a membrane

  2022-04-18

  

  STAR★Methods Introduction γ-Secretase is a membrane-embedded proteolytic complex belonging to a diverse family of intramembrane-cleaving proteases and is composed of four integral membrane proteins: presenilin (PS), nicastrin (NCT), anterior pharynx-defective 1 (Aph-1), and presenilin enhancer

• Some previous findings indicate that GALP has

  2022-04-18

  

  Some previous findings indicate that GALP has an influence on AVP and OT secretion from the posterior pituitary gland. Cunningham et al. (2004) noted that the expression of GALP mRNA was increased in the neurohypophysis of lactating rats compared to non-lactating rats, whereas GALP mRNA expression i

• br Materials and methods br Results and

  2022-04-18

  

  Materials and methods Results and discussion Conclusions Acknowledgements This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684), and also by t

• In the intestine ethanol exposure can change the composition

  2022-04-18

  

  In the intestine, ethanol exposure can change the composition of gut microbiota and promotes the growth of intestinal gram-negative bacteria, which results in the accumulation of endotoxins such as, LPS. Ethanol also impacts the integrity of the gastrointestinal mucosal barrier, increasing intestina

• The G protein coupled receptor GPR also called FFAR

  2022-04-18

  

  The G protein-coupled receptor, GPR40 (also called FFAR1) responds to medium and long chain unsaturated fatty acids, resulting in increase of insulin secretion during elevated glucose levels. The glucose dependency of insulin secretion makes this receptor a very good target for developing therapies

• On the contrary the benzhydrol series

  2022-04-18

  

  On the contrary, the benzhydrol series showed modest activity with EC of two digit micromole. The bulkiness of the CH5138303 synthesis tail may be the reason for the low activity. Interestingly, introduction of H-bonding groups, such as OMe in and CF in , slightly improved the activity compared to

• Sperm exocytosis or acrosome reaction AR is a regulated

  2022-04-16

  

  Sperm exocytosis or acrosome reaction (AR) is a regulated secretion with special characteristics essential for fertilization. The AR relies on the same highly conserved molecules that drive intracellular membrane fusion and exocytosis in all other regadenoson synthesis (see [59] for a recent review

• NeuroHIV is initiated by HIV crossing the blood brain

  2022-04-16

  

  NeuroHIV is initiated by HIV crossing the blood–brain barrier (BBB) to enter the CNS. This is thought to occur primarily via the transmigration of infected CD14+CD16+ monocytes (Williams, 2014), using the monocytes as “Trojan Horses” (Peluso, 1985), although some studies suggest alternate routes of

• In order to establish proper folding and enzymatic

  2022-04-16

  

  In order to establish proper folding and enzymatic activity, G9a and GLP methyltransferases each contain four structural zinc ions. Both PF 1022A contain two distinguishable types of zinc fingers; three Zn(II) ions are chelated in a triangular cluster by 9 cysteines (b, top left), whereas one Zn(II

• Cyanine 5-dUTP The variants all occurred at residues conserv

  2022-04-16

  

  The 17 variants all occurred at residues conserved among vertebrates (Figure 1B) and in regions depleted in missense variants in gnomAD. Indeed, when we assessed missense tolerance ratios for TRRAP, we observed that most of the 17 variants were in regions intolerant to missense variants (Figure 2B).

• Fluorescein-12-dUTP Several named antagonist ligands have fi

  2022-04-16

  

  Several named antagonist ligands have figured noticeably in preclinical studies, with proved clear ability to release neurotransmitters and having efficacy in preclinical animal models. Consequently, this has encouraged ongoing research on improved agents with potency, selectivity, and better drug-l

• Several mechanisms have been suggested

  2022-04-16

  

  Several mechanisms have been suggested to underline the release of signalling molecules from astrocytes: reverse operation of glutamate transporters, volume-regulated anion channels, gap-junctional hemi channels, diffusional release through purinergic receptors and Ca2+-dependent exocytosis [2], [15

• br Prostaglandins meet Hippo The prostaglandins

  2022-04-16

  

  Prostaglandins meet Hippo The prostaglandins lie at the crossroads between inflammation, regeneration and tumorigenesis (Figure 3). Prostaglandins are synthesized from archidonic download the handbook by Cox1 and Cox2 enzymes [40, 41] and in the gut, prostaglandin E2 (PGE2) protects against DSS-

• Several studies have also suggested that Wnt signalling

  2022-04-16

  

  Several studies have also suggested that Wnt signalling can in turn stimulate the transcriptional activity of Yap/Taz (Figure 2, Figure 3). In the Azzolin model, Yap/Taz not only block β-catenin signalling, but their association with Axin1 and/or β-catenin also maintains them in an inactivate state

• In tumor cells HK II induction

  2022-04-16

  

  In tumor cells HK-II induction is mediated by Akt/mTOR pathway [6], [11]. HK-II dynamically shuttles between the mitochondria and cytoplasm under different metabolic conditions. In cardiomyocytes, Akt enhances HK-II binding to mitochondria, setting the heart at a state resistant to ischemic injury [

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