• The CNP pGC B cGMP pathway has been

  2022-04-02

  

  The CNP/pGC-B/cGMP pathway has been reported to be potent inhibitor of fibrosis, from an intrinsic compensatory protective response as well as a therapeutic in cardiorenal injury and disease states [6,12,13,22,30]. Indeed, fibrosis is a progressive process leading to increased risk for morbidity and

• The imidazopyridines and related imidazopyrimidines and

  2022-04-02

  

  The imidazopyridines and related imidazopyrimidines – and – were constructed from the key amine intermediates – ( X=CH and Ar=2-FPh, X=N and Ar=2-FPh, X=CH and Ar=5-pyrimidine, X=CH and Ar=2-methyl-5-pyrimidine, and X=CF and Ar=2-methyl-5-pyrimidine). These were synthesized a modified Horner–Em

• br Cholecystokinin CCK CCK is secreted

  2022-04-02

  

  Cholecystokinin (CCK) CCK is secreted by enteroendocrine I-cells of the duodenum and jejunum in response to amino acids and lipids [14]. There are two forms of the CCK receptor, CCK1 which is expressed on pancreatic α- and β-cells while CCK2 is located on somatostatin-secreting δ-cells [8]. CCK r

• Several studies have found that

  2022-04-02

  

  Several studies have found that GPR55 possesses a distinct pharmacology from that of CB1 and CB2, and that only certain cannabinoids act at this receptor. In transfected R406 expressing hGPR55, out of more than 20 synthetic and endogenous cannabinoids evaluated, only 2 compounds, SR141716A (Rimonab

• br Discovery of GPR A The murine

  2022-04-02

  

  Discovery of GPR109A The murine niacin receptor, protein upregulated in macrophages by interferon-γ (PUMA-G), was identified as a G-protein-coupled receptor (GPCR) expressed in adipocytes and spleen [22], [23]. This finding suggested a role of this receptor in macrophage function [24]. In 2003, t

• Generally speaking the regulation of GnIH

  2022-04-02

  

  Generally speaking, the regulation of GnIH on gonadotropins synthesis and release, although controversial, could be direct and/or indirect via GnRH, among others peptides. In this sense, different scenarios have been reported in vertebrates. In mammalian and avian species, GnIH fibers reach the medi

• Pefloxacin receptor Obestatin increased GnRH mRNA expression

  2022-04-01

  

  Obestatin increased GnRH mRNA expression in the POA, being the main place of GnRH synthesis (Goodman, 2015). Simultaneously, obestatin also caused a decrease in the GnRH mRNA expression in ME, without affecting the level of this peptide mRNA in AHA. A lack of differences observed in the mRNA level i

• br Material and methods br Results br

  2022-04-01

  

  Material and methods Results Discussion The inhibitory action of a GABA agonist, muscimol, on the level of mRNA encoding GnRH in the POA-hypothalamus [25] of follicular-phase sheep has suggested that at the hypothalamic level GABA may exert a suppressive effect on subsequent steps of the Gn

• In this study we present the synthesis and structure activit

  2022-04-01

  

  In this study, we present the synthesis and structure–activity studies of a structurally distinct series possessing high potency and selectivity in HEK cell lines together with a potentially promising overall biopharmacological profile. Focusing on creating sufficient structural dissimilarity with g

• br Regulation of Glu transporters The pivotal

  2022-04-01

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino sodium channels calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include tran

• In this present study the availability of commercial GLUT an

  2022-04-01

  

  In this present study, the availability of commercial GLUT and SGLT A23187, free acid directed against different epitopes, enabled us to screen for members of the SGLT family and compare the expression patterns of GLUTs and SGLTs in the different regions of the rat lens. Based on these regional and

• With the advent of genome sequencing hexokinase

  2022-04-01

  

  With the advent of genome sequencing, hexokinase gene sequences are now available from a far greater number of vertebrate species, as well as from diverse non-vertebrate animal species. As indicated above, searches of vertebrate genome sequences revealed the existence of a novel fifth member of the

• Deregulation of HH signaling pathway in

  2022-04-01

  

  Deregulation of HH signaling pathway in epidermal keratinocytes is a primary event leading to the formation of BCC (see above). Overexpression of SHH in HaCaT keratinocytes grown in organotypic cultures induces a basal cell phenotype and increases invasiveness. This behavior is linked to increased E

• Numerical models of blood regulation provide insight into

  2022-04-01

  

  Numerical models of blood regulation provide insight into the interaction of the cellular-level and macro-scale phenomena studied in silico, a term referring to computer simulations of the dynamics of complex biological systems as opposed to in vivo or in vitro experimental studies. These in silico

• To improve the performance of the immunoassay various nanoma

  2022-04-01

  

  To improve the performance of the immunoassay, various nanomaterials including carbon nanospheres [9], gold nanoparticles [10] and transition metal compounds [11] were used to immobilize natural enzymes as the label. Natural enzymes, such as horseradish peroxidase (HRP) [12] and glucose oxidase (GOD

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