• Previous studies in the Swiss Webster mouse Rosengren

  2020-01-16

  

  Previous studies in the Swiss Webster mouse (Rosengren et al., 1995) and the Sprague–Dawley rat (El Sisi et al., 1993) have shown that retinol pretreatment potentiates the hepatotoxicity of paracetamol. The current study is designed to investigate further this interaction in mice. To accomplish this

• To function as Ub ligases

  2020-01-16

  

  To function as Ub-ligases, E3 proteins must interact with E2s. As compared to the extensive studies on E3s, functional studies on E2s are relatively rudimentary in higher plants. We previously reported that there are 48 genes encoding Ub-conjugating (UBC) fold-containing putative E2 proteins in the

• br UVC induced DNA damage a model to study DNA

  2020-01-16

  

  UVC-induced DNA damage: a model to study DNA damage tolerance The UV components of sunlight that reaches the Earth surface are one of the most carcinogenic agents humans are exposed to, and the leading cause of skin cancer [4,12]. UV light causes different types of DNA damage through indirect and

• DNMT is the dominating enzyme responsible for

  2020-01-16

  

  DNMT1is the dominating enzyme responsible for maintenance of the DNA methylation pattern and the primary enzyme responsible for copying methylation patterns following DNA replication (Moore et al., 2013). DNMT1 maintains the mitotic inheritance of the original methylation pattern in a cell lineage d

• Two in vitro reports using lung fibroblasts

  2020-01-16

  

  Two in vitro reports using lung fibroblasts have shown that cell transmigration, using transwell migration experiments, through collagen I-coated inserts is mediated by DDR2 and the DDR2-associated signaling kinases JAK2 and ERK1/2, but not DDR1 [63] and that DDR2 regulates the adhesion of fibroblas

• Natural progestogens play an important role in the

  2020-01-15

  

  Natural progestogens play an important role in the stimulation of oocyte growth and maturation as well as in spermatogenesis and sperm maturation, and they act as sex pheromones in teleost fish (Kime, 1990, Kobayashi et al., 2002, Nagahama and Yamashita, 2008, Scott et al., 2010). A complex series o

• pyk2 inhibitor br In order to determine the physiological

  2020-01-15

  

  In order to determine the physiological roles of WT (wild type) EWSR1, Dr. Lee\'s group established a conventional Ewsr1 KO mouse [38]. Since then, the Ewsr1 KO (−/−) mouse model has successfully been utilized to decipher many important in vivo roles of EWSR1 (Fig. 1). EWSR1 deficiency alters m

• From an industrial perspective the low turnover numbers and

  2020-01-15

  

  From an industrial perspective, the low turnover numbers and limited substrate scope of α-KG halogenases still represents a significant challenge. However, in light of the fact that currently no chemical processes are available for the selective halogenation of aliphatic carbon centers in complex mo

• In conclusion we have found that Egr

  2020-01-15

  

  In conclusion, we have found that Egr1 can play an inhibitory role on DBH promoter-driven transcription. This inhibition requires a newly identified Egr1 response Nivolumab at the −227/−224 region of DBH promoter. This inhibition appears to result from Egr1 directly bound to the DBH promoter. We sp

• Funding sources This study was funded by European

  2020-01-15

  

  Funding sources This study was funded by European Community’s Seventh Framework Programme under grant agreement No. 305662 (Project: Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial ‘COSMIC’). Acknowledg

• br Introduction br Sphingolipid metabolism Sphingolipids

  2020-01-15

  

  Introduction Sphingolipid metabolism Sphingolipids, are fundamental constituents of all eukaryotic membranes and their metabolism is carried out by a broad array of anabolic and SCF, murine recombinant protein receptor with ceramide as their hub (for a review, (Hannun and Obeid, 2018)). Cerami

• We aim to apply the same technology

  2020-01-15

  

  We aim to apply the same technology to target other collagen-binding proteins using motifs from collagens that are specific for other receptors or matrix components. Previously, we synthesized THP libraries, called Toolkits, composed of an active guest sequence flanked by five GPP host triplets that

• br Material and methods br Results br Discussion In the

  2020-01-15

  

  Material and methods Results Discussion In the present study, twenty strains of Y. enterocolitica were analyzed for their inhibitory potential on cysteine proteases. Five of these strains belonged to bioserotype 4/O:3, which is distinguished for its pathogenicity towards humans. The rest of

• Data presented herein suggest that

  2020-01-15

  

  Data presented herein suggest that competent IL-18BP production in epithelial Cy3 TSA is implemented by epigenetic means based on demethylation of a single CpG site at −45 bp/−44 bp (CpG2) of the human IL18BP promoter. In contrast, retarded IL-18BP production in monocytic cells associates with CpG2

• The interest for lanthanide and actinide

  2020-01-15

  

  The interest for lanthanide and actinide complexes appeared again recently, due to their unique features in the design of Single Molecule Magnets (SMM). Lanthanide SMMs are interesting due to large their intrinsic magnetic anisotropy, but their core 4f orbitals minimally participate in exchange inte

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